Direct or indirect endothelial damage? An unresolved question

Insulin's effect on the liver: "direct or indirect?" continues to be the question.

Previous studies suggest that insulin can inhibit hepatic glucose production (HGP) by both direct and indirect actions. The indirect effects include inhibition of glucagon secretion, reduction in plasma nonesterified fatty acid levels, reduction of the amount of gluconeogenic precursor supplied to the liver, and change in neural input to the liver. A study in this issue of the JCI demonstrates ...

The Executive's Right of Privacy: An Unresolved Constitutional Question

Direct or indirect iodine supplementation of infants?

Iodine is needed for thyroid hormone production and iodine suffi ciency is particularly important during pregnancy, lactation, and infancy owing to the role of thyroid hormones in brain development. A defi ciency of iodine during these life stages can result in impaired child cognition and has been associated with infant mortality. In countries with inadequate iodised salt coverage and iodine d...

Direct or indirect endothelial cell transforming growth factor-β receptor activation initiates arteriolar hyalinosis

Tacrolimus (FK-506) controls organ rejection; however, arteriolar hyalinosis is a frequent complication. By use of mice lacking FK-506-binding protein-12 in endothelial cells, Chiasson and co-workers explored the contribution of endothelial cells and the transforming growth factor-β pathway to define mechanisms of hyalinosis. Absence of this binding protein removed a tonic inhibition to activat...

decreasing out of pocket payment: direct or indirect

0